核糖体合成和翻译后修饰肽（RiPPs）的作用机制。

Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.

Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

J Ind Microbiol Biotechnol. 2021 Jun 4;48(3-4). doi: 10.1093/jimb/kuab005.

Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molecular mechanisms of action that underly those bioactivities. Particular emphasis is placed on RiPP/target interactions for which there is structural information. This detailed mechanism of action work is critical toward the development of RiPPs as therapeutics and can also be used to prioritize hits in RiPP genome mining studies.

天然产物仍然是药物和药物先导的重要来源。天然产物中增长最快的超级类群之一是 RiPPs：核糖体合成和翻译后修饰的肽。RiPPs 具有丰富多样的生物活性。本综述重点介绍了这些生物活性所基于的作用机制的分子实例。特别强调了具有结构信息的 RiPP/靶标相互作用。这种详细的作用机制研究对于 RiPPs 作为治疗剂的开发至关重要，也可用于优先考虑 RiPP 基因组挖掘研究中的命中。