Department of Studies and Research in Chemistry, Kuvempu University, Shankaraghatt 577 451, India.
Bioorg Med Chem Lett. 2012 Jan 15;22(2):898-900. doi: 10.1016/j.bmcl.2011.12.037. Epub 2011 Dec 14.
New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0°C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40μM and 80μM). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form.
新的 2-氯-3-甲酰基喹啉肟酯是通过 2-氯-3-甲酰基喹啉肟与各种苯甲酰氯在三乙胺和二氯甲烷存在下于 0°C 反应合成的。通过中性琼脂糖凝胶电泳在不同浓度（40μM 和 80μM）下研究了一些新的肟酯的 DNA 光裂解研究。琼脂糖凝胶中的裂解产物分析表明，少数喹啉肟酯（3d-i）转化为超螺旋 pUC19 质粒 DNA 为其缺口或线性形式。
