Bourdeanu Laura, Frankel Paul, Yu Wai, Hendrix Gregory, Pal Sumanta, Badr Lina, Somlo George, Luu Thehang
The Sage College, 65 1st Street, Troy, NY 12180, USA.
J Support Oncol. 2012 Jul-Aug;10(4):149-54. doi: 10.1016/j.suponc.2011.10.007. Epub 2012 Jan 4.
Chemotherapy-induced nausea and vomiting (CINV) remain among the most frequently reported distressing side effects associated with anthracycline-based chemotherapy despite significant advances in antiemetic management. The main risk factor for severity of CINV is the emetogenic potential of the chemotherapeutic agents. However, patient-related risk factors have been identified, including genetic makeup. Although studies have noted that ethnicity influences nausea and vomiting in other contexts, there is a paucity of research regarding the impact of ethnicity on CINV. This study was undertaken to evaluate whether Asian women receiving anthracycline-based chemotherapy experience more CINV than non-Asians.
A retrospective, comparative, correlational chart review was performed to abstract the relevant variables.
Data from a convenience sample of 358 women with breast cancer who received chemotherapy with doxorubicin between 2004 and 2008 at City of Hope in Duarte, California, were evaluated. The sample consisted of Caucasians (45%), Hispanics (27.7%), Asians (19.8%), and African Americans (7.5%). The results indicate that Asian women with breast cancer undergoing anthracycline-based chemotherapy experienced statistically significantly more clinically important CINV than their non-Asian counterparts.
The data were collected retrospectively, with a certain population distribution at a specific time.
This study provides interesting preliminary evidence that Asian ethnicity plays a role in the development of severe CINV. When managing chemotherapy toxicities in women with breast cancer, health-care providers should tailor therapy to individual risk profiles. Specifically, consideration of antiemetic therapy should accommodate patient characteristics, such as Asian descent.
尽管在止吐治疗方面取得了重大进展，但化疗引起的恶心和呕吐（CINV）仍然是基于蒽环类化疗最常报告的令人痛苦的副作用之一。CINV严重程度的主要危险因素是化疗药物的致吐潜力。然而，已确定了与患者相关的危险因素，包括基因构成。虽然研究指出种族在其他情况下会影响恶心和呕吐，但关于种族对CINV影响的研究却很少。本研究旨在评估接受基于蒽环类化疗的亚洲女性是否比非亚洲女性经历更多的CINV。
进行回顾性、比较性、相关性图表审查以提取相关变量。
对2004年至2008年期间在加利福尼亚州杜阿尔特市希望之城接受多柔比星化疗的358名乳腺癌女性的便利样本数据进行了评估。样本包括白种人（45%）、西班牙裔（27.7%）、亚洲人（19.8%）和非裔美国人（7.5%）。结果表明，接受基于蒽环类化疗的亚洲乳腺癌女性比非亚洲女性经历了统计学上显著更多的具有临床重要性的CINV。
数据是回顾性收集的，在特定时间有一定的人群分布。
本研究提供了有趣的初步证据，表明亚洲种族在严重CINV的发生中起作用。在管理乳腺癌女性的化疗毒性时，医疗保健提供者应根据个体风险特征调整治疗方案。具体而言，在考虑止吐治疗时应考虑患者特征，如亚洲血统。
