毒蕈碱受体激动剂和拮抗剂：对炎症和免疫的影响。

Muscarinic receptor agonists and antagonists: effects on inflammation and immunity.

作者信息

Verbout Norah G, Jacoby David B

机构信息

School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA 02115, USA.

出版信息

Handb Exp Pharmacol. 2012(208):403-27. doi: 10.1007/978-3-642-23274-9_17.

DOI:10.1007/978-3-642-23274-9_17

PMID:22222708

Abstract

In this chapter, we will review what is known about muscarinic regulation of immune cells and the contribution of immune cell muscarinic receptors to inflammatory disease and immunity. In particular, immune cell expression of cholinergic machinery, muscarinic receptor subtypes and functional consequences of agonist stimulation will be reviewed. Lastly, this chapter will discuss the potential therapeutic effects of selective antagonists on immune cell function and inflammatory disease in recent animal studies and human clinical trials.

摘要

在本章中，我们将回顾有关毒蕈碱对免疫细胞的调节作用以及免疫细胞毒蕈碱受体在炎症性疾病和免疫中的作用的已知信息。特别是，将回顾胆碱能机制在免疫细胞中的表达、毒蕈碱受体亚型以及激动剂刺激的功能后果。最后，本章将讨论选择性拮抗剂在最近的动物研究和人体临床试验中对免疫细胞功能和炎症性疾病的潜在治疗作用。