冠心病染色质重塑因子与转录循环。
CHD chromatin remodelers and the transcription cycle.
作者信息
Murawska Magdalena, Brehm Alexander
机构信息
Institute of Molecular Biology and Tumor Research, Philipps University Marburg, Marburg, Germany.
出版信息
Transcription. 2011 Nov-Dec;2(6):244-53. doi: 10.4161/trns.2.6.17840. Epub 2011 Nov 1.
Abstract
It is well established that ATP-dependent chromatin remodelers modulate DNA access of transcription factors and RNA polymerases by "opening" or "closing" chromatin structure. However, this view is far too simplistic. Recent findings have demonstrated that these enzymes not only set the stage for the transcription machinery to act but are actively involved at every step of the transcription process. As a consequence, they affect initiation, elongation, termination and RNA processing. In this review we will use the CHD family as a paradigm to illustrate the progress that has been made in revealing these new concepts.
摘要
ATP依赖的染色质重塑因子通过“打开”或“关闭”染色质结构来调节转录因子和RNA聚合酶对DNA的访问，这一点已得到充分证实。然而，这种观点过于简单。最近的研究结果表明，这些酶不仅为转录机制的作用搭建了舞台，而且在转录过程的每一步都积极参与。因此，它们影响起始、延伸、终止和RNA加工。在本综述中，我们将以CHD家族为例来说明在揭示这些新概念方面所取得的进展。
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