染色质重塑因子的结构与功能
Structure and Function of Chromatin Remodelers.
机构信息
Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA; Interdisciplinary Biological Sciences Program, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA.
Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA.
出版信息
J Mol Biol. 2021 Jul 9;433(14):166929. doi: 10.1016/j.jmb.2021.166929. Epub 2021 Mar 10.
Abstract
Chromatin remodelers act to regulate multiple cellular processes, such as transcription and DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers have been identified in yeast, each with non-redundant roles within the cell. There has been a recent surge in structural models of chromatin remodelers in complex with their nucleosomal substrate. These structural studies provide new insight into the mechanism of action for individual chromatin remodelers. In this review, we summarize available data for the structure and mechanism of action of the four chromatin remodeling complex families.
摘要
染色质重塑酶通过控制基因组 DNA 的可及性来调节多种细胞过程，如转录和 DNA 修复。在酵母中已经鉴定出了四类染色质重塑酶，它们在细胞中具有非冗余的作用。最近，与核小体底物结合的染色质重塑酶的结构模型数量激增。这些结构研究为单个染色质重塑酶的作用机制提供了新的见解。在这篇综述中，我们总结了四类染色质重塑复合物家族的结构和作用机制的现有数据。
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