UCLA School of Medicine, 760 Westwood Blvd, Los Angeles, CA 90024, United States.
Neuropsychologia. 2012 Feb;50(3):390-5. doi: 10.1016/j.neuropsychologia.2011.12.010. Epub 2011 Dec 28.
The basal ganglia (BG) are involved in executive language functions (i.e., verbal fluency) through their connections with cortical structures. The caudate and putamen receive separate inputs from prefrontal and premotor cortices, and may differentially contribute to verbal fluency performance. We examined BG integrity in relation to lexico-semantic verbal fluency performance among older HIV infected adults.
20 older (50+ years) HIV+ adults underwent MRI and were administered measures of semantic and phonemic fluency. BG (caudate, putamen) regions of interest were extracted.
Performance on phonemic word generation significantly predicted caudate volume, whereas performance on phonemic switching predicted putamen volume.
These findings suggest a double dissociation of BG involvement in verbal fluency tasks with the caudate subserving word generation and the putamen associated with switching. As such, verbal fluency tasks appear to be selective to BG function.
基底神经节（BG）通过与皮质结构的连接参与执行语言功能（即言语流畅性）。尾状核和壳核从前额叶和运动前皮质接收单独的输入，并且可能对言语流畅性表现有不同的贡献。我们研究了基底神经节完整性与老年 HIV 感染成人词汇语义流畅性表现之间的关系。
20 名年龄较大（50 岁以上）的 HIV+ 成年人接受了 MRI 检查，并接受了语义流畅性和语音流畅性测试。提取了基底神经节（尾状核、壳核）的感兴趣区。
语音生成的表现显著预测了尾状核体积，而语音转换的表现则预测了壳核体积。
这些发现表明基底神经节在言语流畅性任务中的参与存在双重分离，尾状核参与单词生成，壳核与转换有关。因此，言语流畅性任务似乎对基底神经节功能具有选择性。
