Tbx2 亚家族基因在小鼠生殖系统发育中的动态表达。
Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system.
机构信息
Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York 10032, USA.
出版信息
Dev Dyn. 2012 Feb;241(2):365-75. doi: 10.1002/dvdy.23710. Epub 2011 Dec 16.
BACKGROUND
Tbx2, Tbx3, Tbx4, and Tbx5, members of the Tbx2 subfamily of T-box transcription factor genes, are important for many aspects of embryonic development and mutations in some human TBX2 subfamily genes cause developmental syndromes. In addition, TBX2 and TBX3 are overexpressed in a variety of cancers, including reproductive system cancers. This study characterizes the expression of Tbx2 subfamily genes during development of the reproductive system.
RESULTS
We show that these genes are expressed in both the internal and external reproductive systems. Tbx2 is expressed in gonads and genital ducts, the Wolffian and Müllerian ducts, while Tbx3 is only expressed in genital ducts. Tbx4 is expressed in embryonic and postnatal germ cells. All four genes are expressed in mesenchyme in external genitalia, with Tbx3 and Tbx5 expression in the epithelium as well.
CONCLUSION
This study lays the foundation for investigation of functional requirements for Tbx2 subfamily genes in development of the mammalian reproductive system.
背景
Tbx2、Tbx3、Tbx4 和 Tbx5 是 T 盒转录因子基因 Tbx2 亚家族的成员，对于胚胎发育的许多方面都很重要，人类 Tbx2 亚家族基因的突变会导致发育综合征。此外，TBX2 和 TBX3 在多种癌症中过度表达，包括生殖系统癌症。本研究描述了 Tbx2 亚家族基因在生殖系统发育过程中的表达情况。
结果
我们发现这些基因在内部和外部生殖系统中均有表达。Tbx2 在性腺和生殖道、沃尔夫管和缪勒管中表达，而 Tbx3 仅在生殖道中表达。Tbx4 在胚胎和出生后的生殖细胞中表达。这四个基因在外生殖器的间充质中均有表达，Tbx3 和 Tbx5 也在上皮细胞中表达。
结论
本研究为研究 Tbx2 亚家族基因在哺乳动物生殖系统发育中的功能需求奠定了基础。
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