Hamilton Institute, National University of Ireland, Maynooth, Ireland.
Science. 2012 Jan 20;335(6066):338-41. doi: 10.1126/science.1213230. Epub 2012 Jan 5.
In response to stimulation, B lymphocytes pursue a large number of distinct fates important for immune regulation. Whether each cell's fate is determined by external direction, internal stochastic processes, or directed asymmetric division is unknown. Measurement of times to isotype switch, to develop into a plasmablast, and to divide or to die for thousands of cells indicated that each fate is pursued autonomously and stochastically. As a consequence of competition between these processes, censorship of alternative outcomes predicts intricate correlations that are observed in the data. Stochastic competition can explain how the allocation of a proportion of B cells to each cell fate is achieved. The B cell may exemplify how other complex cell differentiation systems are controlled.
受到刺激后，B 淋巴细胞会选择多种不同的命运，这些命运对免疫调节很重要。目前尚不清楚每个细胞的命运是由外部导向、内部随机过程还是定向不对称分裂决定的。对数千个细胞的同种型转换、发育为浆母细胞、分裂或死亡的时间进行测量表明，每种命运都是自主和随机追求的。由于这些过程之间的竞争，对替代结果的审查预测了在数据中观察到的复杂相关性。随机竞争可以解释如何将一部分 B 细胞分配到每个细胞命运。B 细胞可以例证其他复杂的细胞分化系统是如何被控制的。
