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评估 HIV 蛋白酶抑制剂的使用与猝死或非出血性卒中风险的关系。

Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke.

机构信息

Copenhagen HIV Programme, University of Copenhagen, Denmark.

出版信息

J Infect Dis. 2012 Feb 15;205(4):535-9. doi: 10.1093/infdis/jir788. Epub 2012 Jan 5.

DOI:10.1093/infdis/jir788
PMID:22223855
Abstract

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

摘要

人们对蛋白酶抑制剂 (PIs) 对心脏传导可能产生的影响表示担忧。我们发现，当前或近期 PIs 暴露与猝死或非出血性卒中之间并无显著关联（校正后的比率比为 1.22；95%置信区间为.95-1.57），但 PIs 的累积暴露与风险增加相关（校正后的比率比为每年每增加 1 年暴露风险增加 1.06；95%置信区间为 1.01-1.11）。

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