Ramos-Sanchez Eduardo Milton, Goto Hiro, Rivero Dolores Helena Rodriguez Ferreira, Mauad Thais, de Souza Fernando Nogueira, Monteiro Andrea Moreira, Gidlund Magnus
Departamento de Imunologia, Instituto de Ciências Biomédicas, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brasil.
Instituto de Medicina Tropical, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brasil.
Mem Inst Oswaldo Cruz. 2014 Jul;109(4):484-7. doi: 10.1590/0074-0276130559.
Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
抗逆转录病毒疗法一直与副作用相关，这些副作用要么源于药物本身，要么与人类免疫缺陷病毒感染的影响有关。在此，我们评估了蛋白酶抑制剂茚地那韦对食用正常或高脂饮食仓鼠的副作用。茚地那韦治疗增加了仓鼠的死亡率，并导致甘油三酯、胆固醇和血糖血清水平升高以及抗氧化型低密度脂蛋白自身抗体减少。该治疗导致了肾脏和心脏的组织病理学改变。这些结果表明，仓鼠是研究抗逆转录病毒药物（如蛋白酶抑制剂）副作用的一个有趣模型。
