Gulati Harveen Kaur, Deshmukh S D, Anand Mani, Morale Vidya, Pande Dilip Purushottamrao, Jadhav Sandip Ekanath
Department of Pathology, Smt. Kashibai Navale Medical College & General Hospital, Narhe, Pune, Maharashtra, India.
Int J Trichology. 2011 Jul;3(2):98-101. doi: 10.4103/0974-7753.90818.
A 65-year-old lady presented with an ulcerated lesion over the occipital region of nine-year duration, an incisional biopsy of which was reported as squamous-cell carcinoma. A wide local excision was performed and the tissue was sent for histopathological examination which revealed a low-grade malignant pilar tumor. Focal invasion and atypia were noted. Immunohistochemical (IHC) analysis revealed positivity for CD34 and calretinin immunomarkers favoring outer root sheath origin. Ki67 immunostains revealed a relatively low immunoreactivity indicating the low-grade nature of the tumor; however, p53 immunostain showed strong diffuse nuclear staining confirming the malignant nature of the tumor. Proliferating pilartumors (PPT) are rare tumors and less than 100 well-documented cases of malignant PPT have been reported so far in the literature. These tumors have been recently classified into benign, low- and high-grade malignant tumors and statistically significant difference was found in their biological behavior. However, we propose that IHC can be of immense value in assisting the subtyping of the tumor, so that the behavior and role of adjuvant therapy can be validated in future studies.
一位65岁女性患者，枕部有一溃疡病变，持续9年，切取活检报告为鳞状细胞癌。行广泛局部切除，组织送去做组织病理学检查，结果显示为低级别恶性毛母细胞瘤。可见局灶性浸润和异型性。免疫组化（IHC）分析显示CD34和钙视网膜蛋白免疫标志物呈阳性，提示外毛根鞘来源。Ki67免疫染色显示免疫反应性相对较低，表明肿瘤级别较低；然而，p53免疫染色显示强烈弥漫性核染色，证实了肿瘤的恶性性质。增殖性毛母细胞瘤（PPT）是罕见肿瘤，迄今为止，文献中报道的恶性PPT完整病例不到100例。这些肿瘤最近被分为良性、低级别和高级别恶性肿瘤，并且发现它们的生物学行为存在统计学显著差异。然而，我们认为免疫组化在辅助肿瘤亚型分类方面具有巨大价值，以便在未来研究中验证辅助治疗的行为和作用。
