Joshi Tejas P, Marchand Sharon, Tschen Jaime
Dermatology, Baylor College of Medicine, Houston, USA.
Dermatology, Dermatology and Laser Medicine of Southeast Texas, Beaumont, USA.
Cureus. 2021 Aug 18;13(8):e17289. doi: 10.7759/cureus.17289. eCollection 2021 Aug.
A malignant proliferating trichilemmal tumor (MPTT) is thought to represent the malignant counterpart of a benign proliferating trichilemmal cyst, a keratin-filled lesion that derives from the outer hair root sheath. The clinical appearance of MPTTs does not always correlate with their histopathologic behavior, emphasizing the need for biopsy and histopathological analysis. Here, we present a 46-year-old African American woman who was evaluated for an ostensibly benign cyst on her scalp that was diagnosed as an MPTT following histopathological examination. She was treated with simple surgical resection that was flush with the cyst margins, followed by Mohs surgery to ensure complete resection. As immunohistochemistry (IHC) has often been used to characterize MPTTs, we also review the various IHC markers reported in the literature.
恶性增殖性外毛根鞘瘤（MPTT）被认为是良性增殖性外毛根鞘囊肿的恶性对应物，后者是一种源自外毛根鞘的充满角蛋白的病变。MPTT的临床表现并不总是与其组织病理学行为相关，这凸显了活检和组织病理学分析的必要性。在此，我们报告一名46岁的非裔美国女性，她因头皮上一个看似良性的囊肿接受评估，经组织病理学检查后被诊断为MPTT。她接受了与囊肿边缘齐平的简单手术切除，随后进行了莫氏手术以确保完全切除。由于免疫组织化学（IHC）常被用于MPTT的特征描述，我们还回顾了文献中报道的各种IHC标志物。
