Hayakawa M, Kosaka K, Sugiyama S, Yokoo K, Aoyama H, Izawa Y, Ozawa T
Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan.
Biochem Int. 1990;21(3):573-9.
It is postulated that toxic substances (burn toxin) synthesized in burned skin are transferred into general circulation and cause multiple organ failure. We found a highly cytotoxic substance, leukotoxin, a linoleate epoxide, exists in burned skin. Leukotoxin, as the name indicates, was synthesized by leukocytes from linoleate as a substrate. The aim of this study is to evaluate the possibility of leukotoxin as a burn toxin. We studied plasma leukotoxin level of four patients with extensive burns (over 50% of body surface area) and examined coagulation studies in these patients. We detected considerable amounts of leukotoxin (11.4 nmol/ml-37.0 nmol/ml) in all patients. Leukotoxin was not detected in the control subjects. Pulmonary edema, cardiac failure, and coagulation abnormalities were found in these patients. Exogeneously administered leukotoxin induced similar pathological conditions in experimental animals to those observed in patients with extensive burns. Hence, it is concluded that leukotoxin is a responsible substance as a burn toxin.
据推测，烧伤皮肤中合成的有毒物质（烧伤毒素）进入全身循环并导致多器官功能衰竭。我们发现烧伤皮肤中存在一种高细胞毒性物质——白细胞毒素，一种亚油酸环氧化物。顾名思义，白细胞毒素是由白细胞以亚油酸为底物合成的。本研究的目的是评估白细胞毒素作为烧伤毒素的可能性。我们研究了4例大面积烧伤（超过体表面积50%）患者的血浆白细胞毒素水平，并对这些患者进行了凝血研究。我们在所有患者中均检测到相当数量的白细胞毒素（11.4 nmol/ml - 37.0 nmol/ml）。对照组未检测到白细胞毒素。这些患者出现了肺水肿、心力衰竭和凝血异常。外源性给予白细胞毒素在实验动物中诱导出与大面积烧伤患者相似的病理状况。因此，得出结论：白细胞毒素是一种作为烧伤毒素的责任物质。
