Corradi A, Menta R, Cambi V, Maccarini P, Cerutti R
Department of Internal Medicine and Nephrology, University of Parma, Ospedale, Maggiore, Italy.
Arzneimittelforschung. 1990 Jul;40(7):830-2.
The pharmacokinetics of iopamidol 370 (Iopamiro), a non-ionic water soluble organic iodine compound, were studied in adults with different degrees of chronic renal failure and in healthy volunteers. After 50 ml were administered i.v., plasma and urine levels were determined. The main pharmacokinetic parameters were calculated on the basis of bi-compartimental open model. There were significant differences from healthy volunteers in t1/2 beta, which increased with the degree of renal failure as the clearance values decreased. t1/2 beta was equal to 1.67 h in healthy volunteers, 4.24 h in patients with mild renal failure and 10.03 h in patients with severe renal failure. The clearance decreased as follows: 0.11 (l/h kg) in healthy volunteers, 0.06 (l/h kg) in patients with mild renal failure and 0.02 (l/h kg) in patients with severe renal failure. No significant differences were found in distribution volume values nor in t1/2 alpha.
对非离子型水溶性有机碘化合物碘帕醇370（碘必乐）的药代动力学在不同程度慢性肾衰竭的成人患者及健康志愿者中进行了研究。静脉注射50毫升后，测定血浆和尿液水平。主要药代动力学参数基于二室开放模型计算得出。在β半衰期方面与健康志愿者存在显著差异，其随肾衰竭程度加重而延长，清除率值降低。健康志愿者的β半衰期为1.67小时，轻度肾衰竭患者为4.24小时，重度肾衰竭患者为10.03小时。清除率降低情况如下：健康志愿者为0.11（升/小时·千克），轻度肾衰竭患者为0.06（升/小时·千克），重度肾衰竭患者为0.02（升/小时·千克）。在分布容积值及α半衰期方面未发现显著差异。
