Beluffi G, Cerutti R, Fiori P, Martini A
Servizio di Radiodiagnostica, IRCCS Policlinico S. Matteo, Pavia.
Radiol Med. 1989 May;77(5):493-5.
This research was aimed at evaluating the pharmacokinetic parameters of iopamidol 370 (a nonionic water organic iodine compound) during ivp in infants and children. All children examined in the study had symptomatic recurrent urinary tract infections; they were divided into three groups according to age (0-24 months; 25-72 months; 73-120 months). The contrast medium was injected in a dose of 1 ml/kg + 6 ml. Blood and urine samples were taken at regular time intervals over a 24-hour period in children, whereas in infants only blood samples were collected. Pharmacokinetic parameters were estimated using a bicompartmental open model, as follows: t1/2 alpha (h) = 0.33; t1/2 beta (h) = 1.92; Vc (l/kg) = 0.40; V beta (l/kg) = 0.20; Cl (l/kg) = 0.16. These values were not significantly different, as far as our patients were concerned, from those reported in literature for adults.
本研究旨在评估碘帕醇370（一种非离子型水有机碘化合物）在婴幼儿和儿童静脉肾盂造影期间的药代动力学参数。研究中所有接受检查的儿童均有症状性复发性尿路感染；根据年龄将他们分为三组（0 - 24个月；25 - 72个月；73 - 120个月）。造影剂的注射剂量为1 ml/kg + 6 ml。儿童在24小时内按固定时间间隔采集血样和尿样，而婴儿仅采集血样。使用二室开放模型估计药代动力学参数，结果如下：t1/2α（小时）= 0.33；t1/2β（小时）= 1.92；Vc（升/千克）= 0.40；Vβ（升/千克）= 0.20；Cl（升/千克）= 0.16。就我们的患者而言，这些值与文献中报道的成人值无显著差异。
