Falconer J
Faculty of Medicine, University of Newcastle, N.S.W., Australia.
Alcohol Alcohol. 1990;25(4):413-6.
Intravenous infusion of 1 g ethanol/min over 1 hr to seven catheterised pregnant ewes decreased blood flow on both sides of the placenta. The reductions in blood flow were maintained for at least 2 hr after the infusion of ethanol had ceased. Although blood flow was reduced, fetal blood gases were unchanged. Plasma glucose concentrations were unchanged by ethanol, but fetal glucose supply and consumption were both decreased following maternal ethanol infusions. If maintained by chronic alcohol consumption these changes could contribute to the growth retardation seen in the Fetal Alcohol Syndrome.
对七只插入导管的怀孕母羊在1小时内以每分钟1克乙醇的速度进行静脉输注，结果显示胎盘两侧的血流量均减少。在停止输注乙醇后，血流量的减少至少持续了2小时。尽管血流量减少，但胎儿血气并未改变。乙醇并未改变血浆葡萄糖浓度，但母体输注乙醇后，胎儿葡萄糖供应和消耗均减少。如果因长期饮酒而维持这些变化，可能会导致胎儿酒精综合征中出现的生长迟缓。
