Division of Vascular Surgery, London Health Sciences Centre and the University of Western Ontario, London, Ontario, Canada.
J Vasc Surg. 2012 Apr;55(4):924-8. doi: 10.1016/j.jvs.2011.10.094. Epub 2012 Jan 5.
The purpose of this study was to evaluate patients undergoing elective repair of infrarenal abdominal aortic aneurysms (AAAs) and the longitudinal trends in surgical management (open repair vs endovascular aneurysm repair [EVAR]), factors associated with the choice of surgical technique, and differences in the rate of in-hospital mortality at a single large-volume Canadian center.
This retrospective cohort study used data from a prospectively collected vascular surgery database and reviewed all patients undergoing elective repair of an infrarenal AAA over a recent 10-year period (June 2000-May 2010). Information was reviewed regarding surgical techniques, patient demographics, and short-term outcomes. Subsequent analysis included univariate statistics and multivariable logistic regression with data presented as odds ratios (ORs) and 95% confidence intervals (CIs).
A total of 1942 patients underwent elective AAA repair over this 10-year study period, 1067 (54.9%) via open repair and 875 (45.1%) via EVAR. The proportion of patients undergoing EVAR was significantly higher in the latter half of the study period compared to the first half (55.8% vs 33.9%; P < .01). Older patients (75 vs 71; P < .01) and those with higher American Society of Anesthesiologists classifications (P < .01) were more likely to receive endovascular repair than open repair. The overall in-hospital mortality rate in the entire cohort was low (2.3% for EVAR and 3.9% for open repair), and after multivariable logistic regression and adjustment for preoperative factors, in-hospital mortality was significantly higher in patients with open AAA repair (OR, 1.8; 95% CI, 1.04-3.13; P = .04).
This 10-year analysis shows a significant shift toward an endovascular approach in the repair of infrarenal AAAs at our Canadian center. Similar to other jurisdictions, higher risk and older patients are more likely to be treated with an endovascular repair resulting in a survival advantage in these patients compared to standard open repair.
本研究旨在评估择期修复肾下腹部主动脉瘤(AAA)患者的情况,以及手术治疗的纵向趋势(开放修复与血管内修复[EVAR])、与手术技术选择相关的因素,以及在单一大型加拿大中心住院死亡率的差异。
这项回顾性队列研究使用了前瞻性收集的血管外科数据库中的数据,回顾了最近 10 年(2000 年 6 月至 2010 年 5 月)期间所有择期修复肾下 AAA 的患者信息。研究内容包括手术技术、患者人口统计学和短期结果。随后的分析包括单变量统计和多变量逻辑回归,数据以比值比(ORs)和 95%置信区间(CIs)呈现。
在这项 10 年的研究期间,共有 1942 例患者接受了择期 AAA 修复,其中 1067 例(54.9%)采用开放修复,875 例(45.1%)采用 EVAR。在后半段研究期间,接受 EVAR 的患者比例明显高于前半段(55.8%比 33.9%;P<.01)。较年长的患者(75 岁比 71 岁;P<.01)和美国麻醉医师协会分类较高的患者(P<.01)更有可能接受血管内修复而非开放修复。整个队列的住院死亡率较低(EVAR 为 2.3%,开放修复为 3.9%),经多变量逻辑回归和术前因素调整后,接受开放 AAA 修复的患者住院死亡率显著升高(OR,1.8;95%CI,1.04-3.13;P=.04)。
这项 10 年分析表明,在我们的加拿大中心,肾下 AAA 修复的血管内方法有了显著转变。与其他司法管辖区类似,高风险和较年长的患者更有可能接受血管内修复,与标准开放修复相比,这些患者的生存优势明显。