Sarmaga Don, Dubois Jeffrey A, Lyon Martha E
Calgary Laboratory Services, Calgary, Alberta, Canada.
J Diabetes Sci Technol. 2011 Nov 1;5(6):1449-52. doi: 10.1177/193229681100500617.
Off-meter dosed photometric glucose-oxidase-based glucose meters have been reported to be susceptible to interference by hydrogen-peroxide-based disinfecting agents. The objective of this study was to determine if a single application of hydrogen-peroxide-containing Accel® wipe to disinfect an on-meter dosed amperometric glucose-oxidase-based glucose meter will influence its performance.
The performance of five on-meter dosed amperometric glucose-oxidase-based glucose meters was determined before and after disinfecting the devices with a single application of either CaviWipes® (14.3% isopropanol and 0.23% diisobutyl-phenoxy-ethoxyethyl dimethyl benzyl ammonium chloride) or Accel (0.5% hydrogen peroxide) wipes. Replicate glucose measurements were conducted before disinfecting the devices, immediately after disinfecting, and then 1 and 2 min postdisinfecting, with measurements in triplicate. Analysis was sequentially completed for five different meters. Results were analyzed by a two-way analysis of variance (Analyze-it software).
No clinical (<0.3 mmol/liter) or statistical differences (p > .05) in glucose concentration were detected when the on-meter dosed amperometric glucose-oxidase-based glucose meters were disinfected with either CaviWipes or Accel wipes and measured immediately or 1 or 2 min postdisinfecting. No clinically significant difference in glucose concentration was detected between meters (<0.3 mmol/liter).
The on-meter dosed glucose oxidase amperometric-based glucose meters are not analytically susceptible to interference by a single application of hydrogen-peroxide-containing Accel disinfectant wipes.
据报道，非血糖仪定量的基于葡萄糖氧化酶的血糖仪易受基于过氧化氢的消毒剂干扰。本研究的目的是确定单次使用含过氧化氢的Accel擦拭布对血糖仪定量的基于葡萄糖氧化酶的安培型血糖仪进行消毒是否会影响其性能。
使用CaviWipes（14.3%异丙醇和0.23%二异丁基苯氧基乙氧基乙基二甲基苄基氯化铵）或Accel（0.5%过氧化氢）擦拭布对五台血糖仪定量的基于葡萄糖氧化酶的安培型血糖仪进行单次消毒，在消毒前后分别测定其性能。在消毒前、消毒后立即以及消毒后1分钟和2分钟进行重复葡萄糖测量，测量一式三份。对五台不同的血糖仪依次完成分析。结果采用双向方差分析（Analyze-it软件）进行分析。
当使用CaviWipes或Accel擦拭布对血糖仪定量的基于葡萄糖氧化酶的安培型血糖仪进行消毒，并在消毒后立即或1分钟或2分钟进行测量时，未检测到葡萄糖浓度的临床差异（<0.3 mmol/升）或统计学差异（p>.05）。各血糖仪之间未检测到葡萄糖浓度的临床显著差异（<0.3 mmol/升）。
血糖仪定量的基于葡萄糖氧化酶的安培型血糖仪在分析上不易受到单次使用含过氧化氢的Accel消毒擦拭布的干扰。
