NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, United Kingdom.
J Cyst Fibros. 2012 May;11(3):209-15. doi: 10.1016/j.jcf.2011.12.001. Epub 2012 Jan 4.
Skeletal muscle weakness is an important complication of chronic respiratory disease. The effect of acute exacerbations on strength in patients with cystic fibrosis is not known.
Quadriceps (QMVC) and respiratory muscle strength were measured in patients at the time of acute admission, at discharge and one month later. Patients wore an activity monitor during admission and at one month. Convalescent values were compared to the stable clinic population.
Data were available for 13 acute admissions and 25 stable CF outpatients. Strength and other parameters including daily step count did not differ significantly between the stable and one month post-admission groups. At admission, QMVC was 16.7 (8.3)% lower than at convalescence, whereas inspiratory muscle strength did not change significantly. Reduction in QMVC did not correlate with activity levels or with markers of systemic inflammation.
Further research is needed to identify the mechanisms responsible for the reduction in QMVC.
骨骼肌无力是慢性呼吸道疾病的一个重要并发症。急性加重对囊性纤维化患者的力量的影响尚不清楚。
在急性入院时、出院时和一个月后测量患者的股四头肌（QMVC）和呼吸肌力量。患者在入院期间和一个月时佩戴活动监测器。恢复期的值与稳定的临床人群进行比较。
数据可用于 13 例急性入院和 25 例稳定的 CF 门诊患者。稳定期和入院后一个月组之间的力量和其他参数，包括每日步数，没有显著差异。入院时，QMVC 比恢复期低 16.7（8.3）%，而吸气肌力量没有明显变化。QMVC 的减少与活动水平或全身炎症标志物无关。
需要进一步研究以确定导致 QMVC 减少的机制。
