大多数早期胰腺上皮内瘤变中存在体细胞突变。
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.
机构信息
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Gastroenterology. 2012 Apr;142(4):730-733.e9. doi: 10.1053/j.gastro.2011.12.042. Epub 2012 Jan 5.
Abstract
More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
摘要
需要更多关于启动胰腺上皮内瘤变（胰腺导管腺癌最常见的前体）发展的遗传因素的信息。我们表明，超过 99%的最早阶段、最低级别、胰腺上皮内瘤变 1 病变含有 KRAS、p16/CDKN2A、GNAS 或 BRAF 的突变。这些发现可以提高我们对这些癌前病变发展和进展的理解。
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