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反复发作的与癫痫相关的头部外伤是否会影响癫痫患者的发作?

Do recurrent seizure-related head injuries affect seizures in people with epilepsy?

机构信息

Department of Neurology, Baylor College of Medicine, Houston, TX, USA.

出版信息

Epilepsy Behav. 2012 Feb;23(2):159-61. doi: 10.1016/j.yebeh.2011.11.003. Epub 2012 Jan 9.

DOI:10.1016/j.yebeh.2011.11.003
PMID:22227592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4509506/
Abstract

Seizure-related head injuries (SRHIs) are among the most commonly encountered injuries in people with epilepsy (PWE). Whether head injury has an effect on preexisting epilepsy is not known. The purpose of this study was to systematically assess for any possible effects of SRHIs on seizure frequency and seizure semiology over a 2-year period. We identified 204 patients who have been followed at the Baylor Comprehensive Epilepsy Center from 2008 to 2010. SRHI occurred in 18.1% of the cohort. Most injuries (91%) were classified as mild. Though seizure frequency varied following head injury, overall seizure frequency was not significantly impacted by presence or absence of SRHI over the 2-year study period. Changes in seizure semiology were not observed in those with SRHIs. Although mild SRHI is common among PWE, it does not appear to have an effect on seizure characteristics over a relatively short period.

摘要

与癫痫发作相关的头部损伤(SRHIs)是癫痫患者(PWE)最常见的损伤之一。头部损伤是否对既有癫痫产生影响尚不清楚。本研究的目的是系统评估 2 年内 SRHIs 对癫痫发作频率和发作表现的任何可能影响。我们从 2008 年至 2010 年在 Baylor 综合癫痫中心随访了 204 名患者。该队列中 18.1%的患者发生了 SRHI。大多数损伤(91%)为轻度。尽管头部损伤后癫痫发作频率有所变化,但在 2 年的研究期间,SRHI 的存在或缺失并未显著影响癫痫发作频率。在发生 SRHIs 的患者中未观察到发作表现的变化。尽管轻度 SRHI 在 PWE 中很常见,但在相对较短的时间内,它似乎对癫痫特征没有影响。

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本文引用的文献

1
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Epilepsy Behav. 2010 Nov;19(3):400-4. doi: 10.1016/j.yebeh.2010.07.029. Epub 2010 Sep 18.
2
Factors influencing self-rated health in traffic-related mild traumatic brain injury.交通相关轻度创伤性脑损伤中影响自评健康的因素。
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3
Seizure-related injuries are underreported in pharmacoresistant localization-related epilepsy.在抗药性局灶性相关癫痫中,与癫痫发作相关的损伤报告不足。
Epilepsia. 2010 Jan;51(1):43-7. doi: 10.1111/j.1528-1167.2009.02170.x. Epub 2009 Jun 10.
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Epilepsia. 2008 Aug;49(8):1440-5. doi: 10.1111/j.1528-1167.2008.01601.x. Epub 2008 Apr 10.
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Exacerbation of pre-existing epilepsy by mild head injury: a five patient series.轻度头部损伤导致既往癫痫病情加重:5例病例系列报道
Can J Neurol Sci. 2004 Aug;31(3):394-7. doi: 10.1017/s0317167100003516.
7
Cognitive dysfunction in young men following head injury in childhood and adolescence: a population study.童年和青少年时期头部受伤后年轻男性的认知功能障碍:一项人群研究。
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):933-6. doi: 10.1136/jnnp.74.7.933.
8
Morbidity and accidents in patients with epilepsy: results of a European cohort study.癫痫患者的发病率与事故:一项欧洲队列研究的结果
Epilepsia. 2002 Sep;43(9):1076-83. doi: 10.1046/j.1528-1157.2002.18701.x.
9
Current concepts: diffuse axonal injury-associated traumatic brain injury.当前概念:弥漫性轴索损伤相关的创伤性脑损伤
Arch Phys Med Rehabil. 2001 Oct;82(10):1461-71. doi: 10.1053/apmr.2001.25137.
10
Relationship between concussion and neuropsychological performance in college football players.大学橄榄球运动员脑震荡与神经心理表现之间的关系。
JAMA. 1999 Sep 8;282(10):964-70. doi: 10.1001/jama.282.10.964.