Choi Hyunmi, Heiman Gary, Pandis Dionysis, Cantero Julio, Resor Stanley R, Gilliam Frank G, Hauser W Allen
Department of Neurology, The Neurological Institute, Columbia University, New York, New York 10032, USA.
Epilepsia. 2008 Aug;49(8):1440-5. doi: 10.1111/j.1528-1167.2008.01601.x. Epub 2008 Apr 10.
To investigate the cumulative probabilities of >or=12 month seizure remission and seizure relapse following remission, and to test the associations of clinical characteristics with these two study end points in a prevalence cohort of intractable adult epilepsy patients during medical management.
A retrospective cohort study of intractable epilepsy patients seen in 2001 at a single center was conducted. Kaplan-Meier analysis was used to estimate the cumulative probabilities of seizure remission and subsequent seizure relapse. Cox proportional hazards models were used to estimate the association (1) between clinical factors and >or=12 month seizure remission and (2) between clinical factors and seizure relapse following remission.
One hundred eighty-seven subjects met the eligibility criteria for intractable epilepsy. The estimate of probability of remission was about 4% per year. Seizure remission was temporary for some individuals, as 5 out of 20 subjects with remission ultimately relapsed. No clinical factors predicted the likelihood of achieving >or=12 month seizure remission or subsequent seizure relapse.
Some people with intractable epilepsy achieve >or=12 month seizure remission during medical treatment. Remission, however, is only temporary for some individuals. We were unable to identify clear predictors for remission.
调查难治性成人癫痫患者在药物治疗期间≥12个月癫痫发作缓解及缓解后癫痫复发的累积概率，并检验临床特征与这两个研究终点之间的关联。
对2001年在单一中心就诊的难治性癫痫患者进行回顾性队列研究。采用Kaplan-Meier分析来估计癫痫发作缓解及随后癫痫复发的累积概率。使用Cox比例风险模型来估计（1）临床因素与≥12个月癫痫发作缓解之间以及（2）临床因素与缓解后癫痫复发之间的关联。
187名受试者符合难治性癫痫的纳入标准。缓解概率估计约为每年4%。部分个体的癫痫发作缓解是暂时的，因为20名缓解的受试者中有5名最终复发。没有临床因素能预测达到≥12个月癫痫发作缓解或随后癫痫复发的可能性。
一些难治性癫痫患者在药物治疗期间实现了≥12个月的癫痫发作缓解。然而，缓解对部分个体只是暂时的。我们未能确定明确的缓解预测因素。
