Department of Pharmacology, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin 150086, China.
Sci China Life Sci. 2011 Dec;54(12):1097-102. doi: 10.1007/s11427-011-4241-3. Epub 2012 Jan 7.
Atrial fibrillation (AF) remains one of the leading causes of morbidity and mortality in the world which are related to palpitations, fainting, congestive heart failure or stroke. The mechanism for atrial fibrillation has been identified as electrical remodeling, structure remodeling and intracellular calcium handling remodeling. microRNAs (miRNAs) have recently emerged as one of the important factors in regulating gene expression. So far, thousands of miRNA genes have been found in diverse animals with the function of regulating cell death, cell proliferation, haematopoiesis and even participate in the processing of cardiovascular disease. In this review, we summarize the mechanism of AF and the association of microRNAs network with AF. We provide a potential perspective of miRNAs as the therapeutic target for AF.
心房颤动（AF）仍然是世界上发病率和死亡率的主要原因之一，与心悸、晕厥、充血性心力衰竭或中风有关。心房颤动的机制已被确定为电重构、结构重构和细胞内钙处理重构。microRNAs（miRNAs）最近被认为是调节基因表达的重要因素之一。到目前为止，在各种动物中已经发现了数千个 miRNA 基因，其功能包括调节细胞死亡、细胞增殖、造血，甚至参与心血管疾病的处理。在这篇综述中，我们总结了 AF 的机制以及 miRNA 网络与 AF 的关联。我们提供了 miRNA 作为 AF 治疗靶点的潜在前景。
