Pediatrics Department, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal.
Eur J Pediatr. 2012 May;171(5):851-4. doi: 10.1007/s00431-011-1667-3. Epub 2012 Jan 7.
Kawasaki disease (KD) is an acute, self-limiting, idiopathic form of vasculitis. The preventive effect of early therapy on coronary artery aneurysms, the hallmark of the disease, is well established. The spectrum of complication includes not only cardiac involvement but also central nervous system lesions. We report a 4-year-old boy with a clinical presentation suggestive of KD treated with intravenous immunoglobulin and acetylsalicylic acid. Clinical manifestations regressed within 24 hours and cardiac anomalies were not seen. Two weeks later, the parents noticed a sudden absence of response to sound stimuli. Investigations confirmed bilateral severe sensorineural hearing loss for which oral steroid therapy was given. This resulted in an improvement only on the right side, with severe hearing loss persisting on the left.
Sensorineural hearing loss is an uncommonly reported complication of KD. Pediatricians should be aware of this potential complication to allow for early intervention.
川崎病（KD）是一种急性、自限性、特发性血管炎。早期治疗对冠状动脉瘤这一疾病特征的预防作用已得到充分证实。其并发症谱不仅包括心脏受累，还包括中枢神经系统病变。我们报告了一例 4 岁男孩，临床表现提示川崎病，给予静脉注射免疫球蛋白和乙酰水杨酸治疗。临床表现在 24 小时内消退，未发现心脏异常。两周后，父母注意到患儿对声音刺激突然无反应。检查证实为双侧严重感觉神经性听力损失，给予口服类固醇治疗。右侧听力有所改善，但左侧仍严重听力损失。
感觉神经性听力损失是川崎病少见的并发症。儿科医生应意识到这种潜在的并发症，以便早期干预。
