Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, China.
Mol Carcinog. 2012 Oct;51 Suppl 1:E118-22. doi: 10.1002/mc.21872. Epub 2012 Jan 6.
Single-nucleotide polymorphisms (SNPs) of TERT rs2736098, rs2736100, and CLPTM1L rs402710 at 5p15.33 are significantly associated with risk of a spectrum of cancers. However, cervical cancer has been rarely evaluated. In this study, we genotyped the three SNPs in a case-control study with 1,033 cervical cancer cases and 1,053 cancer-free controls in a Chinese population. Logistic regression analyses showed that the two TERT SNPs both significantly associated with cervical cancer risk in the recessive model (rs2736098, AA vs.
AG/GG: adjusted OR = 1.35, 95% CI = 1.06-1.72; rs2736100, CC vs. AC/AA: adjusted OR = 1.38, 95% CI = 1.11-1.73). However, no association was found between CLPTM1L rs402710 and cervical cancer. These results suggest that genetic variants in 5p15.33, especially in TERT, may be markers for susceptibility to cervical cancer.
端粒酶逆转录酶（TERT）rs2736098、rs2736100 和 5p15.33 上的 CLPTM1L rs402710 单核苷酸多态性（SNPs）与多种癌症的风险显著相关。然而，宫颈癌很少被评估。在这项研究中，我们在中国人群中对 1033 例宫颈癌病例和 1053 例无癌症对照进行了病例对照研究，对这三个 SNPs 进行了基因分型。逻辑回归分析表明，两个 TERT SNPs 均在隐性模型中与宫颈癌风险显著相关（rs2736098，AA 与 AG/GG：调整后的 OR = 1.35，95%CI = 1.06-1.72；rs2736100，CC 与 AC/AA：调整后的 OR = 1.38，95%CI = 1.11-1.73）。然而，CLPTM1L rs402710 与宫颈癌之间没有关联。这些结果表明，5p15.33 中的遗传变异，特别是 TERT 中的遗传变异，可能是宫颈癌易感性的标志物。
