Department of Pharmaceutical Chemistry, K. B. Institute of Pharmaceutical Education and Research, Sector-23, Gandhinagar-382023, Gujarat, India.
Phytother Res. 2012 Aug;26(8):1259-61. doi: 10.1002/ptr.3708. Epub 2012 Jan 6.
Dyslipidaemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. Lipid changes associated with diabetes mellitus are attributed to increases in free fatty acid flux, secondary to insulin resistance. In the present study, we have investigated the beneficial effects of swertiamarin on dyslipidaemic conditions associated with type 2 diabetes in streptozotocin-induced type 2 diabetic rats. Swertiamarin (50 mg/kg, i.p.) administered once a day for 6 weeks resulted in significant (p < 0.001) reductions in serum triglycerides, cholesterol and low-density lipoprotein levels in diabetic animals as compared with diabetic control animals. Serum fasting glucose was significantly (p < 0.05) decreased, moreover, the insulin sensitivity index was significantly (p < 0.05) increased in swertiamarin treated animals. Overall the data suggest that swertiamarin has beneficial effects on diabetic associated complications such as dyslipidaemia.
血脂异常是糖尿病患者心血管疾病的主要危险因素之一。与糖尿病相关的脂质变化归因于游离脂肪酸通量的增加，这是胰岛素抵抗的继发结果。在本研究中，我们研究了獐牙菜苦苷对链脲佐菌素诱导的 2 型糖尿病大鼠 2 型糖尿病相关血脂异常的有益作用。獐牙菜苦苷（50mg/kg，腹腔注射）每天给药一次，持续 6 周，与糖尿病对照组动物相比，糖尿病动物的血清甘油三酯、胆固醇和低密度脂蛋白水平显著降低（p<0.001）。血清空腹血糖显著降低（p<0.05），此外，獐牙菜苦苷治疗动物的胰岛素敏感指数显著升高（p<0.05）。总的来说，这些数据表明獐牙菜苦苷对糖尿病相关并发症如血脂异常具有有益的作用。
