静电纺丝纤维模板用于微形貌神经生长导向的复制成型。

Electrospun fiber template for replica molding of microtopographical neural growth guidance.

机构信息

CAS Key lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing 100190, China.

出版信息

Small. 2012 Mar 12;8(5):676-81. doi: 10.1002/smll.201101199. Epub 2012 Jan 9.

DOI:10.1002/smll.201101199

PMID:22228650

Abstract

A method for replica molding electrospun (ES) fibers on the surface of polydimethylsiloxane (PDMS) is developed for culturing and guiding of cells, instead of ES fibers. With this method, microgrooves and microstructures composed of microgrooves can be obtained. PDMS is integrated into the microfluidic chip as a substrate to successfully pattern and guide neurites on the PDMS surface with microgrooves.

摘要

一种在聚二甲基硅氧烷（PDMS）表面复制电纺（ES）纤维的方法被开发出来，用于细胞的培养和引导，而不是 ES 纤维。通过这种方法，可以获得由微槽组成的微结构。PDMS 被集成到微流控芯片中作为基底，成功地在 PDMS 表面的微槽上对神经突进行图案化和引导。