Sersa G, Miklavcic D
Institute of Oncology, Laboratory of Immunology, Ljubljana, Yugoslavia.
Mol Biother. 1990 Sep;2(3):165-8.
A preliminary study of the antitumor effect of partially purified human interferon alpha (IFN-alpha) and low-level direct current (DC) was carried out using a murine subcutaneous SA-1 experimental tumor model. Tumor-bearing animals were treated with 5 x 10(4) IU IFN-alpha peritumorally, or with 0.6 mA DC current for 15 minutes daily, for 6 consecutive days. Antitumor effect was manifested 2 days after the beginning of each treatment modality. Combined treatment with DC current applied immediately after IFN-alpha application was more effective than IFN-alpha treatment alone (P less than 0.005), but not significantly better than DC current treatment (P less than 0.5). The results indicate that the combined treatment with IFN-alpha and DC current can be effective in tumor therapy; however, further work is required to determine optimal scheduling.
使用小鼠皮下SA-1实验性肿瘤模型，对部分纯化的人α干扰素（IFN-α）和低强度直流电（DC）的抗肿瘤作用进行了初步研究。荷瘤动物分别接受以下处理：瘤周注射5×10⁴国际单位的IFN-α，或每天接受0.6毫安直流电照射15分钟，连续6天。每种治疗方式开始后2天即显现出抗肿瘤效果。IFN-α注射后立即施加直流电的联合治疗比单独使用IFN-α治疗更有效（P<0.005），但并不显著优于直流电治疗（P<0.5）。结果表明，IFN-α与直流电联合治疗对肿瘤治疗可能有效；然而，需要进一步研究以确定最佳治疗方案。
