产前接触大麻的长期影响以及内源性大麻素在发育中大脑的作用。
Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain.
作者信息
Wu Chia-Shan, Jew Christopher P, Lu Hui-Chen
机构信息
The Cain Foundation Laboratories, Jan & Dan Duncan Neurological Research Institute at Texas Children's Hospital, 1250 Moursund St Suite 1225, Houston, TX 77030, USA.
出版信息
Future Neurol. 2011 Jul 1;6(4):459-480. doi: 10.2217/fnl.11.27.
Abstract
Cannabis is the most commonly used illicit substance among pregnant women. Human epidemiological and animal studies have found that prenatal cannabis exposure influences brain development and can have long-lasting impacts on cognitive functions. Exploration of the therapeutic potential of cannabis-based medicines and synthetic cannabinoid compounds has given us much insight into the physiological roles of endogenous ligands (endocannabinoids) and their receptors. In this article, we examine human longitudinal cohort studies that document the long-term influence of prenatal exposure to cannabis, followed by an overview of the molecular composition of the endocannabinoid system and the temporal and spatial changes in their expression during brain development. How endocannabinoid signaling modulates fundamental developmental processes such as cell proliferation, neurogenesis, migration and axonal pathfinding are also summarized.
摘要
大麻是孕妇中最常用的非法物质。人类流行病学和动物研究发现，产前接触大麻会影响大脑发育，并对认知功能产生长期影响。对大麻类药物和合成大麻素化合物治疗潜力的探索，让我们对内源性配体（内源性大麻素）及其受体的生理作用有了更深入的了解。在本文中，我们研究了记录产前接触大麻长期影响的人类纵向队列研究，随后概述了内源性大麻素系统的分子组成及其在大脑发育过程中的表达时空变化。还总结了内源性大麻素信号如何调节细胞增殖、神经发生、迁移和轴突寻路等基本发育过程。
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