Division of Cardiology, Department of Internal Medicine, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China.
Clin Exp Pharmacol Physiol. 2012 Mar;39(3):241-6. doi: 10.1111/j.1440-1681.2012.05667.x.
The effects of amiodarone on ventricular electrophysiological parameters, especially the dispersion of ventricular repolarization, were investigated in a canine model of congestive heart failure (CHF). Dogs were randomized to either a control, amiodarone, CHF, or CHF+amiodarone group. Dogs in the CHF and CHF+amiodarone groups underwent 4-5 weeks of rapid ventricular pacing; dogs in the control and amiodarone groups underwent sham operation only. Amiodarone (20 mg/kg per day) was administered orally, beginning on postoperative Day 1, in the treatment groups; ventricular electrophysiological variables were evaluated 4-5 weeks after rapid pacing or sham operation. In CHF dogs, the transmural dispersion ventricular repolarization time (TDVRT) increased significantly. Amiodarone significantly decreased the TDVRT in CHF dogs. The ventricular fibrillation threshold (VFT) decreased in the CHF group. Amiodarone increased the VFT in CHF dogs. The TDVRT increased in CHF dogs, but amiodarone decreased TDVRT and increased VFT in these dogs. These results suggest a beneficial effect of amiodarone on malignant arrhythmias and may provide the basis for its use in CHF patients.
在充血性心力衰竭（CHF）犬模型中研究了胺碘酮对心室电生理参数的影响，特别是对心室复极离散度的影响。将狗随机分为对照组、胺碘酮组、CHF 组和 CHF+胺碘酮组。CHF 和 CHF+胺碘酮组的狗接受了 4-5 周的快速心室起搏；对照组和胺碘酮组的狗仅接受假手术。胺碘酮（每天 20mg/kg）在治疗组中从术后第 1 天开始口服给予；在快速起搏或假手术后 4-5 周评估心室电生理变量。在 CHF 狗中，跨室壁复极离散时间（TDVRT）显著增加。胺碘酮可显著降低 CHF 狗的 TDVRT。CHF 组的室颤阈值（VFT）降低。胺碘酮增加了 CHF 狗的 VFT。TDVRT 在 CHF 狗中增加，但胺碘酮降低了这些狗的 TDVRT 并增加了 VFT。这些结果表明胺碘酮对恶性心律失常有有益的影响，并可为其在 CHF 患者中的应用提供依据。
