胺碘酮对右心室快速起搏诱导的心力衰竭犬心脏电生理的影响。

Effects of amiodarone on cardiac electrophysiology in right ventricular rapid pacing-induced heart failure dogs.

作者信息

Zhou S X, Zhang X M, Wu W, Chen X C

机构信息

Department of Internal Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.

出版信息

Zhongguo Yao Li Xue Bao. 1998 Jul;19(4):363-8.

PMID:10375786

Abstract

AIM

To study the effects of amiodarone (Ami) on cardiac electrophysiologic properties and ventricular fibrillation threshold (VFT) in right ventricular rapid pacing-induced congestive heart failure (CHF) dogs.

METHODS

Dogs (n = 25) were randomly allocated into 3 groups: A) control group; B) CHF group induced by right ventricular rapid pacing (4 pulses.s-1) for 4-5 wk; C) CHF models p Ami 300 mg.d-1 for 4-5 wk. The electrophysiologic parameters and VFT were evaluated by electric stimulation and monophasic action potential (MAP) recording.

RESULTS

In CHF models, ventricular MAP duration (MAPD90), ventricular late repolarization duration (VLRD), and intra-ventricular conduction time (IVCT) were prolonged by 43%, 318%, and 19%, respectively; the ratio of ventricular effective refractory period (VERP) to MAPD90 (VERP/ MAPD90) and VFT were decreased by 13% and 48% respectively; the dispersion of ventricular recovery time (RT-D) was increased by 185%. In CHF models, Ami had no effects on ventricular MAPD90, but increased VERP/ MAPD90, IVCT, and VFT by 15%, 10%, and 67%, respectively, shortened VLRD by 87%; and decreased RT-D by 87%. Ami had no significant influences on the hemodynamic parameters of the CHF dogs.

CONCLUSION

Ami normalizes the cardiac electrophysiologic properties in CHF dogs.

摘要

目的

研究胺碘酮（Ami）对右心室快速起搏诱导的充血性心力衰竭（CHF）犬心脏电生理特性及室颤阈值（VFT）的影响。

方法

将25只犬随机分为3组：A）对照组；B）通过右心室快速起搏（4次脉冲·秒⁻¹）诱导4 - 5周的CHF组；C）CHF模型组，给予Ami 300 mg·d⁻¹，持续4 - 5周。通过电刺激和单相动作电位（MAP）记录评估电生理参数和VFT。

结果

在CHF模型中，心室MAP持续时间（MAPD90）、心室晚期复极持续时间（VLRD）和心室内传导时间（IVCT）分别延长43%、318%和19%；心室有效不应期（VERP）与MAPD90的比值（VERP/MAPD90）和VFT分别降低13%和48%；心室恢复时间离散度（RT - D）增加185%。在CHF模型中，Ami对心室MAPD90无影响，但使VERP/MAPD90、IVCT和VFT分别增加15%、10%和67%，使VLRD缩短87%；使RT - D降低87%。Ami对CHF犬的血流动力学参数无显著影响。