Expert Opin Emerg Drugs. 2012 Mar;17(1):5-9. doi: 10.1517/14728214.2012.652946. Epub 2012 Jan 10.
Cancer cachexia is a multifactorial syndrome characterized by progressive skeletal muscle wasting and weakness. It affects most patients with advanced cancers, reduces quality of life and accounts for more than 20% of all cancer-related deaths. A number of promising therapies for cancer cachexia are in development, including appetite stimulants, anti-inflammatory drugs and those targeting catabolism. However, the multifactorial pathogenesis indicates strongly that the most effective treatments will come from drug combination approaches. Drug treatments should ideally be combined with exercise training to maximize efficacy and ultimately reduce mortality and enhance the quality of life of patients with cancer cachexia.
癌症恶病质是一种多因素综合征，其特征为进行性骨骼肌消耗和无力。它影响大多数晚期癌症患者，降低生活质量，并导致超过 20%的与癌症相关的死亡。目前有许多针对癌症恶病质的有前途的治疗方法正在开发中，包括食欲刺激剂、抗炎药和针对分解代谢的药物。然而，这种多因素发病机制强烈表明，最有效的治疗方法将来自药物联合治疗方法。药物治疗最好与运动训练相结合，以最大限度地提高疗效，最终降低癌症恶病质患者的死亡率并提高其生活质量。
