Tecnobios Procreazione Centre for Reproductive Health, Via Dante 15, 40125 Bologna Italy.
Curr Pharm Des. 2012;18(3):293-302. doi: 10.2174/138161212799040420.
Thanks to the recent advances in cancer care, more and more young women can survive but suffer from infertility as a result of cancer treatment that had to be submitted. There are a variety of methods to preserve fertility, as chemoprotection, ovariopexy, and some assisted reproductive technologies, although some of these are promising but still highly experimental techniques. Cryopreservation of embryos for example is already established, while the oocyte banking is still considered an experimental practice. Many experiments have been conducted around the world on the cryopreservation of ovarian tissue and maturation of ovarian follicles, in an attempt to demonstrate its potential use in fertility preservation. Although in recent years there has been major improvements in the preservation of ovarian tissue, there are still many unresolved technical issues related to these procedures. In this chapter we examine the recent evidence of the pathophysiology of chemotherapy / radiotherapy-induced gonadal toxicity, and recent data regarding the indications and results of the techniques used to preserve fertility in women with cancer.
由于癌症治疗的最新进展，越来越多的年轻女性可以存活下来，但由于不得不接受的癌症治疗而导致不孕。有多种方法可以保留生育能力，如化学保护、卵巢固定术和一些辅助生殖技术，尽管其中一些方法很有前途，但仍然是高度实验性的技术。例如，胚胎冷冻保存已经确立，而卵母细胞冷冻保存仍被认为是一种实验性做法。世界各地已经进行了许多关于卵巢组织冷冻保存和卵巢卵泡成熟的实验，试图证明其在生育力保存中的潜在用途。尽管近年来在卵巢组织保存方面取得了重大进展，但这些手术仍存在许多悬而未决的技术问题。在本章中，我们检查了化疗/放疗诱导性腺毒性的病理生理学的最新证据，以及关于用于保留癌症女性生育能力的技术的适应症和结果的最新数据。
