Young E W, McCarron D A, Morris C D
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201.
Am J Hypertens. 1990 Aug;3(8 Pt 2):161S-166S. doi: 10.1093/ajh/3.8.161.
Alterations of calcium metabolism have been described in human essential hypertension and experimental hypertension. We investigated the interrelationship of parathyroid hormone (PTH) and 1,25(OH)2-vitamin D (1,25(OH)2D) in patients with untreated essential hypertension as compared to normotensive controls. The hypertensive subjects (n = 75; 43 men, 32 women) had a mean blood pressure of 138 +/- 8/95 +/- 5 mm Hg as compared with 120 +/- 11/80 +/- 8 in the normotensive group (n = 40; 22 men, 18 women). Serum PTH was measured with an intact molecule immunochemiluminometric assay and 1,25(OH)2D was measured with radioimmunoassay after HPLC separation. Hypertensive men had PTH levels that were 36% higher than normotensive men (5.3 +/- 2.9 v 3.9 +/- 0.8 pmol/L, P = .005). When blood pressure was analyzed as a continuous variable, there was a direct correlation between it and serum PTH in men (r = .31, P = .004). In women, by contrast, there was no difference in serum PTH between hypertensive and normotensive subjects and no relationship between blood pressure and the serum PTH concentration. Blood pressure was inversely correlated with serum phosphorus levels in both sexes (r = -0.20, P = .04). In men, the elevated serum PTH levels and depressed serum phosphorus levels would have predicted that serum 1,25(OH)2D would be higher in the hypertensive subjects. However, that was not observed, as serum 1,25(OH)2D was slightly lower in hypertensive (38.3 +/- 15.2 pg/mL) than normotensive men (42.7 +/- 11.3, P = .21).(ABSTRACT TRUNCATED AT 250 WORDS)
人体原发性高血压和实验性高血压中均有钙代谢改变的相关描述。我们研究了未经治疗的原发性高血压患者与血压正常的对照组中甲状旁腺激素（PTH）和1,25-二羟维生素D（1,25(OH)₂D）之间的相互关系。高血压受试者（n = 75；43名男性，32名女性）的平均血压为138±8/95±5 mmHg，而血压正常组（n = 40；22名男性，18名女性）的平均血压为120±11/80±8 mmHg。采用完整分子免疫化学发光法测定血清PTH，采用高效液相色谱分离后放射免疫法测定1,25(OH)₂D。高血压男性的PTH水平比血压正常男性高36%（5.3±2.9对3.9±0.8 pmol/L，P = .005）。当将血压作为连续变量分析时，男性的血压与血清PTH之间存在直接相关性（r = .31，P = .004）。相比之下，女性高血压患者与血压正常者的血清PTH无差异，血压与血清PTH浓度之间也无关联。两性的血压均与血清磷水平呈负相关（r = -0.20，P = .04）。在男性中，血清PTH水平升高和血清磷水平降低本应预示高血压受试者的血清1,25(OH)₂D会更高。然而，并未观察到这种情况，因为高血压男性的血清1,25(OH)₂D（38.3±15.2 pg/mL）略低于血压正常男性（42.7±11.3，P = .21）。（摘要截选至250词）
