Saleh F, Jorde R, Svartberg J, Sundsfjord J
Department of Internal Medicine B, University Hospital of North Norway, 9038 Tromsø, Norway.
J Endocrinol Invest. 2006 Mar;29(3):214-20. doi: 10.1007/BF03345542.
The aim of the present cross-sectional epidemiological study from Tromsø, Northern Norway, was to evaluate the relation between blood pressure and serum PTH, and to examine whether this relation can be explained by a blood pressure-induced increase in urinary calcium. Ten thousand-four hundred and nineteen subjects were invited to participate and 8,128 attended. Those with serum calcium outside the reference range (2.20-2.60 mmol/l), with increased serum creatinine (upper limit 120 micromol/l for men and 100 micromol/l for women) and those using antihypertensive medication were excluded. Three thousand- six hundred and twenty subjects had complete data on outcome measures. Height, weight, blood pressure, serum calcium, PTH, and creatinine were measured and smoking status recorded. A morning urine sample was collected and urinary calcium, sodium and creatinine measured. The urinary calcium/urinary creatinine ratio (Uca/Ucr) and urinary sodium/urinary creatinine ratio (Una/Ucr) were calculated. There was a significant association between both systolic and diastolic blood pressure and serum PTH. The Uca/Ucr increased with increasing blood pressure. However, the Uca/Ucr did not affect the association between blood pressure and serum PTH in a multiple linear regression model. The relationship between blood pressure and serum PTH was also seen in subjects with similar Uca/Ucr, and a negative association between serum PTH and the Uca/Ucr was found. In conclusion, blood pressure and serum PTH are associated. This association cannot be explained by the urinary calcium excretion alone.
来自挪威北部特罗姆瑟的这项横断面流行病学研究的目的是评估血压与血清甲状旁腺激素（PTH）之间的关系，并检验这种关系是否可由血压引起的尿钙增加来解释。10419名受试者受邀参与，8128人参加。排除血清钙超出参考范围（2.20 - 2.60 mmol/L）、血清肌酐升高（男性上限120 μmol/L，女性上限100 μmol/L）以及正在使用抗高血压药物的受试者。3620名受试者有关于结局指标的完整数据。测量身高、体重、血压、血清钙、PTH和肌酐，并记录吸烟状况。收集晨尿样本并测量尿钙、尿钠和肌酐。计算尿钙/尿肌酐比值（Uca/Ucr）和尿钠/尿肌酐比值（Una/Ucr）。收缩压和舒张压与血清PTH之间均存在显著关联。Uca/Ucr随血压升高而增加。然而，在多元线性回归模型中，Uca/Ucr并未影响血压与血清PTH之间的关联。在Uca/Ucr相似的受试者中也观察到了血压与血清PTH之间的关系，并且发现血清PTH与Uca/Ucr之间呈负相关。总之，血压与血清PTH相关。这种关联不能仅由尿钙排泄来解释。
