Brickman A S, Nyby M D, von Hungen K, Eggena P, Tuck M L
Division of Endocrinology, Sepulveda Veterans Administration Medical Center, Calif.
Hypertension. 1990 Nov;16(5):515-22. doi: 10.1161/01.hyp.16.5.515.
Plasma ionized calcium, platelet cytosolic calcium (using the fura-2 method in gel-filtered platelets), parathyroid hormone (both the intact hormone and a midmolecule portion), calcitriol, and calcidiol were measured in 19 untreated male patients with essential hypertension and 19 age-matched normotensive male research subjects. Mean levels of platelet cytosolic calcium, parathyroid hormone, calcitriol, and calcidiol were all significantly higher, whereas plasma ionized calcium was significantly lower, in the hypertensive group compared with the normotensive group. Both platelet cytosolic calcium and intact parathyroid hormone were positively correlated with mean arterial pressure (r = 0.58, p less than 0.001; r = 0.54, p less than 0.001, respectively), whereas plasma ionized calcium was inversely correlated with mean arterial pressure (r = -0.60, p less than 0.001) in the combined group of all study subjects. All three of these correlations were significant in the hypertensive group alone but not in the normotensive group alone. When analyzed with plasma ionized calcium, body mass index, serum calcitriol, and calcidiol in a multivariable regression model, the significance of the partial regressions of platelet cytosolic calcium and parathyroid hormone with mean arterial pressure persisted. Intact parathyroid hormone was positively correlated to platelet cytosolic calcium (r = 0.43, p less than 0.01) and plasma ionized calcium was inversely correlated to platelet cytosolic calcium (r = -0.44, p less than 0.01). These results confirm previous reports of disturbances of calcium metabolism in essential hypertension and suggest that the elevated platelet cytosolic calcium observed in essential hypertension may be linked to one or more of these alterations of calcium metabolism.
对19例未经治疗的原发性高血压男性患者和19例年龄匹配的血压正常男性研究对象，测定了血浆离子钙、血小板胞浆钙（采用凝胶过滤血小板中的fura-2法）、甲状旁腺激素（包括完整激素和中分子部分）、骨化三醇和骨化二醇。与血压正常组相比，高血压组的血小板胞浆钙、甲状旁腺激素、骨化三醇和骨化二醇的平均水平均显著升高，而血浆离子钙显著降低。在所有研究对象的合并组中，血小板胞浆钙和完整甲状旁腺激素均与平均动脉压呈正相关（r分别为0.58，p<0.001；r为0.54，p<0.001），而血浆离子钙与平均动脉压呈负相关（r=-0.60，p<0.001）。这三种相关性在单独的高血压组中均显著，但在单独的血压正常组中不显著。当在多变量回归模型中用血浆离子钙、体重指数、血清骨化三醇和骨化二醇进行分析时，血小板胞浆钙和甲状旁腺激素与平均动脉压的偏回归显著性仍然存在。完整甲状旁腺激素与血小板胞浆钙呈正相关（r=0.43，p<0.01），血浆离子钙与血小板胞浆钙呈负相关（r=-0.44，p<0.01）。这些结果证实了先前关于原发性高血压中钙代谢紊乱的报道，并表明在原发性高血压中观察到的血小板胞浆钙升高可能与这些钙代谢改变中的一种或多种有关。
