与核心启动子元件相关的意外特征。
The unexpected traits associated with core promoter elements.
作者信息
Dikstein Rivka
机构信息
Department of Biological Chemistry, The Weizmann Institute of Science; Rehovot, Israel.
出版信息
Transcription. 2011 Sep-Oct;2(5):201-6. doi: 10.4161/trns.2.5.17271.
Abstract
The core promoter of eukaryotic coding and non-coding genes that are transcribed by RNA polymerase II (RNAP II) is composed of DNA elements surrounding the transcription start site. These elements serve as the docking site of the basal transcription machinery and have an important role in determining the position and directing the rate of transcription initiation. This review summarizes the current knowledge about core promoter elements and focuses on several unexpected links between core promoter structure and certain gene features. These include the association between the presence or absence of a TATA-box and gene length, gene structure, gene function, evolution rate and transcription elongation.
摘要
由RNA聚合酶II（RNAP II）转录的真核生物编码基因和非编码基因的核心启动子由围绕转录起始位点的DNA元件组成。这些元件作为基础转录机制的停靠位点，在确定转录起始的位置和指导转录起始速率方面发挥着重要作用。本综述总结了目前关于核心启动子元件的知识，并着重探讨了核心启动子结构与某些基因特征之间的几个意外联系。这些联系包括TATA框的有无与基因长度、基因结构、基因功能、进化速率和转录延伸之间的关联。
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