Akine Y, Arimoto H, Ogino T, Kajiura Y, Tsukiyama I, Egawa S, Yamada T, Tanemura K, Tsunematsu R, Ohmi K
Department of Radiation Therapy, National Cancer Center, Tokyo, Japan.
Acta Oncol. 1990;29(6):747-53. doi: 10.3109/02841869009092994.
Six hundred and twelve patients with previously untreated invasive carcinoma of the uterine cervix were treated by irradiation alone at the National Cancer Hospital from 1972 to 1983. The number of patients was 7, 39, 43, 127, 15, 319, 28 and 34 in stages IA, IB, IIA, IIB, IIIA, IIIB, IVA and IVB respectively. Low-dose-rate intracavitary irradiation with or without external irradiation was used in 383 patients, high-dose-rate intracavitary irradiation with or without external irradiation in 130, external irradiation alone in 98, and external irradiation combined with radon-222 seed implantation in one patient. Five-year-survival rates were 85, 65, 57, 41, 14 11% for stages IB, IIA, IIB, IIIB, IVA, and IVB respectively. The rate of complications was rather high in the present series, and so we have been investigating whether it is possible to reduce the dose. Low-dose-rate intracavitary irradiation has been replaced by high-dose-rate irradiation by using a remotely controlled afterloading system.
1972年至1983年期间，国立癌症医院对612例未经治疗的子宫颈浸润癌患者仅采用放射治疗。IA期、IB期、IIA期、IIB期、IIIA期、IIIB期、IVA期和IVB期的患者人数分别为7例、39例、43例、127例、15例、319例、28例和34例。383例患者采用了低剂量率腔内照射联合或不联合外照射，130例采用了高剂量率腔内照射联合或不联合外照射，98例仅采用外照射，1例采用外照射联合222氡籽植入。IB期、IIA期、IIB期、IIIB期、IVA期和IVB期的5年生存率分别为85%、65%、57%、41%、14%和11%。本系列并发症发生率相当高，因此我们一直在研究是否有可能降低剂量。低剂量率腔内照射已被使用遥控后装系统的高剂量率照射所取代。
