高剂量率腔内照射治疗子宫颈癌：84例患者的早期经验

High-dose-rate intracavitary irradiation in the treatment of carcinoma of the uterine cervix: early experience with 84 patients.

作者信息

Akine Y, Arimoto H, Ogino T, Kajiura Y, Tsukiyama I, Egawa S, Yamada T, Tanemura K, Tsunematsu R, Ohmi K

机构信息

Department of Radiation Therapy, National Cancer Center, Tokyo, Japan.

出版信息

Int J Radiat Oncol Biol Phys. 1988 May;14(5):893-8. doi: 10.1016/0360-3016(88)90011-9.

DOI:10.1016/0360-3016(88)90011-9

PMID:3360656

Abstract

Eighty-four patients with previously untreated invasive carcinoma of the uterine cervix were treated by high-dose-rate intracavitary irradiation using a remotely controlled afterloading system (Ralstron) with or without external irradiation at the National Cancer Center Hospital, Tokyo, between 1977 and 1981. Survival rates and local control rates were comparable to those for 372 patients treated by low-dose-rate intracavitary irradiation with or without external irradiation from 1972 to 1981 at the hospital. The incidence of major complications was 5.1 and 2.4% for the patients treated by low-dose-rate intracavitary irradiation and by high-dose-rate irradiation, respectively. The results are comparable to those reported by other institutions. We have abandoned the conventional low-dose-rate intracavitary irradiation with the impression that the high-dose-rate remotely controlled afterloading system is a good alternative to the conventional one.

摘要

1977年至1981年间，东京国立癌症中心医院对84例既往未经治疗的子宫颈浸润癌患者采用遥控后装系统（Ralstron）进行高剂量率腔内照射，部分患者联合或不联合外照射。1972年至1981年间，该医院对372例患者采用低剂量率腔内照射联合或不联合外照射进行治疗，其生存率和局部控制率与此类似。低剂量率腔内照射组和高剂量率照射组患者的主要并发症发生率分别为5.1%和2.4%。这些结果与其他机构报告的结果相当。我们已放弃传统的低剂量率腔内照射，认为高剂量率遥控后装系统是传统方法的良好替代方案。