Grau C, Zachariae C, Mao H S, Overgaard J
Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus.
Acta Oncol. 1990;29(6):769-74. doi: 10.3109/02841869009092997.
The potential chemosensitizing effect of the nitroaromatic radiosensitizer misonidazole (MISO) on the alkylating agent cyclophosphamide (CTX), and the interactions of these agents with radiation, have been investigated in a C3H mammary carcinoma in CDF1 mice. MISO at 1,000 mg/kg caused a small increase in tumour growth time (TGT; time to reach 3 times treatment volume) from 3.6 days to 4.5 days. CTX (100 mg/kg) increased the TGT to 15.7 days. The combined treatment of MISO and CTX given with intervals of either 15 min or 4 h increased the TGT to 23.3 and 23.8 days respectively. The radiation enhancement ratio (ER) was found to be 2.13 and 1.10 for MISO administered before or after x-rays respectively. The corresponding ERs for CTX were 1.16 and 1.22. The two drugs given in combination resulted in significant radiation ERs of 2.68 (both drugs given within 30 min before x-rays), 3.00 (MISO 30 min before and CTX 3 1/2 h after x-rays) and 1.40 (both drugs given after x-rays). In contrast to what has previously been reported, and in contrast to the tumour regrowth delay data, the results of the tumour control experiments were found to reflect no more than an additive action of the two drugs when used together with radiation in vivo.
在CDF1小鼠的C3H乳腺癌模型中，研究了硝基芳香族放射增敏剂米索硝唑（MISO）对烷化剂环磷酰胺（CTX）的潜在化学增敏作用，以及这些药物与辐射的相互作用。1000mg/kg的MISO使肿瘤生长时间（TGT；达到治疗体积3倍的时间）从3.6天小幅增加至4.5天。CTX（100mg/kg）使TGT增加至15.7天。间隔15分钟或4小时联合给予MISO和CTX，TGT分别增加至23.3天和23.8天。发现X射线照射前或照射后给予MISO的辐射增强比（ER）分别为2.13和1.10。CTX相应的ER分别为1.16和1.22。联合给予这两种药物导致显著的辐射ER，分别为2.68（两种药物均在X射线照射前30分钟内给予）、3.00（MISO在X射线照射前30分钟给予，CTX在照射后3.5小时给予）和1.40（两种药物均在X射线照射后给予）。与之前报道的情况以及肿瘤再生长延迟数据相反，肿瘤控制实验结果表明，在体内与辐射联合使用时，这两种药物的作用不超过相加作用。
