单次高剂量或慢性低剂量米索硝唑增强烷化剂的作用。
Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
作者信息
McNally N J, Hinchliffe M, de Ronde J
出版信息
Br J Cancer. 1983 Aug;48(2):271-8. doi: 10.1038/bjc.1983.182.
Abstract
Misonidazole (MISO) given as a large single dose enhanced the action of cyclophosphamide (Cy) and melphalan (L-PAM) in two mouse tumours. Below a dose of about 500 mg kg-1 it had no chemosensitizing effect. When MISO was given as a series of small doses by repeat injection over an 8 h period, in order to stimulate human pharmacokinetics, it significantly enhanced the action of Cy in the SA F tumour. It also enhanced the action of Cy and L-PAM in the WHFIB tumour as assayed by tumour cell survival in vitro following treatment in vivo but not when the assay was tumour growth delay. There was no enhancement by MISO of the leukopenia due to Cy or L-PAM. The results suggest that, in some tumours there may be benefit from the combination of clinically relevant MISO doses with alkylating agents. The leucopenia induced by these agents should not be enhanced by the MISO.
摘要
大剂量单次给予米索硝唑（MISO）可增强环磷酰胺（Cy）和美法仑（L-PAM）对两种小鼠肿瘤的作用。剂量低于约500mg/kg时，它没有化学增敏作用。为模拟人体药代动力学，在8小时内通过重复注射给予一系列小剂量的MISO时，它可显著增强Cy对SA F肿瘤的作用。在体内治疗后通过体外肿瘤细胞存活情况测定，它还增强了Cy和L-PAM对WHFIB肿瘤的作用，但在通过肿瘤生长延迟进行测定时则不然。MISO不会增强由Cy或L-PAM引起的白细胞减少。结果表明，在某些肿瘤中，临床相关剂量的MISO与烷化剂联合使用可能有益。MISO不会增强这些药物引起的白细胞减少。
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本文引用的文献
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