Ichiba N
Department of Pediatrics, Okayama University Medical School.
No To Hattatsu. 1990 Sep;22(5):436-44.
To clarify the pathogenesis of mental deterioration in epilepsy, neuropsychological and electroencephalographic studies were performed. Thirty-seven children were classified into two groups: group I consisted of 24 children with mental deterioration during the clinical course of their epilepsy, and group II consisted of 13 children without mental deterioration. Mental deterioration was assessed on the basis of the intelligence test scores during follow-up studies. The mean intelligence quotient of 24 children in group I decreased from 91.8 +/- 11.5 to 64.3 +/- 15.4 during a mean period of 4.4 years. Significant differences were found between the two groups in the levels of both representation (association function) and automation (auditory closure, visual recognition and visual-motor function). There were also significant differences between the two groups in the continuation of epileptic discharges on EEG, in the persistence of epileptic attacks at the final visit, and in the numbers of antiepileptic drugs at the neuropsychological examination. The degree of mental deterioration was correlated with the defect in the association function and, eleven children in group I showed mental deterioration even after their attacks had been suppressed.
为阐明癫痫患者智力衰退的发病机制，我们进行了神经心理学和脑电图研究。37名儿童被分为两组：第一组由24名在癫痫临床病程中出现智力衰退的儿童组成，第二组由13名未出现智力衰退的儿童组成。在随访研究中，根据智力测试分数评估智力衰退情况。第一组24名儿童的平均智商在平均4.4年的时间里从91.8±11.5降至64.3±15.4。两组在表象（联想功能）和自动化（听觉闭合、视觉识别和视动功能）水平上存在显著差异。两组在脑电图上癫痫放电的持续情况、最后一次就诊时癫痫发作的持续情况以及神经心理学检查时抗癫痫药物的数量方面也存在显著差异。智力衰退程度与联想功能缺陷相关，并且第一组中有11名儿童即使在发作得到控制后仍出现智力衰退。
