Department of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK.
Ir J Med Sci. 2012 Dec;181(4):479-82. doi: 10.1007/s11845-011-0802-5. Epub 2012 Jan 10.
The elevated risk of triggering a myocardial infarction by smoking cannabis is limited to the first 2 h after smoking.
To examine the possible role of cannabis in cardiac deaths. CASES AND RESULTS: From 3,193 coroners' cases over 2 years, there were 13 cases where the clinical information was compatible with a primary cardiac cause of death. An inquest was held in three cases. Myocardial infarction was the primary cause of death in 54%. Other causes were sudden adult death syndrome, sudden death in epilepsy, and poisoning by alcohol and diazepam. Cannabis was mentioned once only on a death certificate, but not as a cause of death. Blood delta9-tetrahydrocannabinol-carboxylic acid was recorded in one case and in no case was plasma tetrahydrocannabinol (THC) measured.
To attribute sudden cardiac death to cannabis, plasma THC should be measured in the toxicology screen in coroners' cases where urine cannabinoids are positive. A positive urine cannabinoids immunoassay alone is insufficient evidence in the linkage of acute cardiac death and cannabis.
吸烟大麻会增加心肌梗死的风险，这种风险仅限于吸烟后 2 小时内。
探讨大麻在心脏性猝死中的可能作用。
在 2 年期间的 3193 例尸检案例中，有 13 例临床信息符合原发性心脏原因死亡。其中 3 例进行了死因调查。心肌梗死是导致 54%死亡的主要原因。其他原因包括成人突发性死亡综合征、癫痫猝死和酒精及地西泮中毒。在一份死亡证明中仅提到过一次大麻，但并未将其作为死因。仅在一个案例中记录了血液中 δ9-四氢大麻酸-羧基，并且在任何情况下都未测量血浆四氢大麻酚（THC）。
在毒理学筛查中，对于出现尿液大麻素阳性的尸检案例，如果要将突发性心脏死亡归因于大麻，则应测量血浆 THC。仅尿液大麻素免疫分析呈阳性不足以证明急性心脏死亡与大麻之间存在关联。
