Anić Branimir, Cerovec Mislav
Zavod za klinicku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinicki bolnicki centar Zagreb, Kispatićeva 12, 10000 Zagreb.
Reumatizam. 2011;58(2):36-8.
Seronegative spondyloarthritides are inflammatory rheumatic diseases which are classified together because of numerous common and similar clinical, epidemiologic and genetic characteristics. Pathogenesis of seronegative spondyloarthritides is usually described as development of clinical characteristics of the disease in genetically susceptible person in the presence of favorable environmental factors. Development of seronegative spondyloarthritides, notably ankylosing spondylitis, is strongly connected with presence of the HLA-B27 gene. There are clear evidence that HLA-B27 positive individuals have significantly higher risk for disease development. The role of infection in occurence of seronegative spondyloarthritides is not completely understood--its role is better clarified in the case of reactive arthritis than in ankylosing spondylitis. The relation between HLA-B27 gene and infection is not clarified. Molecular mimicry theory is based on similarities between HLA-B27 molecule and microbial particle.
血清阴性脊柱关节病是一类炎性风湿性疾病，由于众多共同且相似的临床、流行病学和遗传学特征而被归为一类。血清阴性脊柱关节病的发病机制通常被描述为在遗传易感性个体中，在有利的环境因素存在下疾病临床特征的发展。血清阴性脊柱关节病，尤其是强直性脊柱炎的发病与HLA - B27基因的存在密切相关。有明确证据表明HLA - B27阳性个体患该病的风险显著更高。感染在血清阴性脊柱关节病发生中的作用尚未完全明确——其在反应性关节炎中的作用比在强直性脊柱炎中更清楚。HLA - B27基因与感染之间的关系尚未阐明。分子模拟理论基于HLA - B27分子与微生物颗粒之间的相似性。
