记忆门诊人群夜间氧饱和度下降的神经认知相关性。
Neurocognitive correlates of nocturnal oxygen desaturation in a memory clinic population.
机构信息
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
出版信息
J Clin Exp Neuropsychol. 2012;34(3):325-32. doi: 10.1080/13803395.2011.642849. Epub 2012 Jan 10.
Abstract
Previous studies suggested that sleep apnea is associated with neurocognitive impairments but did not examine populations most likely to have clinically relevant impairments. Cross-sectional, retrospective analyses were performed on 108 patients (65 with mild cognitive impairment, 43 with dementia) seen in an academic medical center. Results indicated that severity of oxygen desaturation was associated with cognitive impairments in attention and executive function domains, even after controlling for age, sex, education, and depressive symptoms. Strength of associations was influenced by cardiovascular disease. Screening for nocturnal oxygen desaturation may be a useful procedure to assess for a potentially reversible cause of cognitive impairment.
摘要
先前的研究表明，睡眠呼吸暂停与神经认知障碍有关，但并未研究最有可能出现临床相关障碍的人群。对在学术医疗中心就诊的 108 名患者（65 名轻度认知障碍，43 名痴呆）进行了横断面、回顾性分析。结果表明，即使在控制年龄、性别、教育程度和抑郁症状等因素后，缺氧严重程度仍与注意力和执行功能领域的认知障碍有关。关联的强度受心血管疾病的影响。夜间缺氧的筛查可能是评估认知障碍潜在可逆转原因的有用程序。
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