Department of Psychology, National Taiwan University, Taipei 10617, Taiwan.
Parkinsonism Relat Disord. 2012 Dec;18(10):1067-72. doi: 10.1016/j.parkreldis.2012.06.002. Epub 2012 Jun 30.
Given the importance of early detection and intervention for disease management, determining the vulnerable neuropsychological function in patients with early-stage Parkinson's disease (PD) is a priority. Here, we describe the neuropsychological pattern in early-stage PD patients with mild cognitive impairment (PD-MCI) and dementia (PDD) in Taiwanese population. The neuropsychological performance of 94 patients with PD was compared with that of 84 healthy controls (HCs) and available normative data, using a comprehensive neuropsychological assessment including tests of executive, memory, psychomotor speed, attention, visuospatial, and language functions. Our results showed that PD patients performed significantly worse on executive function (i.e., category of card sorting) and psychomotor speed (i.e., processing speed index). Up to 46.8% were classified as PD-MCI and the majority of those having single-domain impairment (68.2%); 9.6% met the consensus diagnostic criteria for PDD. Accordingly, we suggest that early-stage PD patients have cognitive dysfunction predominately in the anterior brain. Further follow-up study to determine how many percent of PD-MCI develop PDD is important. The effect of neurocognitive rehabilitation on executive function is also valuable in the subsequence study.
鉴于早期发现和干预对于疾病管理的重要性，确定早期帕金森病（PD）患者中脆弱的神经心理学功能是当务之急。在这里，我们描述了台湾地区早期 PD 患者伴轻度认知障碍（PD-MCI）和痴呆（PDD）的神经心理学模式。使用包括执行功能、记忆、运动速度、注意力、视空间和语言功能测试在内的综合神经心理学评估，比较了 94 例 PD 患者与 84 例健康对照者（HCs）和可用的常模数据的神经心理学表现。我们的结果表明，PD 患者在执行功能（即分类卡片分类）和运动速度（即处理速度指数）方面的表现明显较差。多达 46.8%的患者被归类为 PD-MCI，其中大多数（68.2%）存在单一领域的损害；9.6%符合 PDD 的共识诊断标准。因此，我们建议早期 PD 患者的认知功能障碍主要在前脑。进一步的随访研究以确定有多少 PD-MCI 会发展为 PDD 非常重要。后续研究中，神经认知康复对执行功能的影响也很有价值。
