Department of Biological Chemistry, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Naka-ku, Sakai, Japan.
J Agric Food Chem. 2012 Feb 8;60(5):1193-200. doi: 10.1021/jf2043357. Epub 2012 Jan 27.
The breakdown of collagenous networks with aging results in hypoactive changes in the skin. Accordingly, reviving stagnant collagen synthesis can help protect dermal homeostasis against aging. We searched for type I collagen biosynthesis-inducing substances in various foods using human dermal fibroblasts and found that cinnamon extract facilitates collagen biosynthesis. Cinnamon extract potently up-regulated both mRNA and protein expression levels of type I collagen without cytotoxicity. We identified cinnamaldehyde as a major active component promoting the expression of collagen by HPLC and NMR analysis. Since insulin-like growth factor-I (IGF-I) is the most potent stimulator of collagen biosynthesis in fibroblasts, we examined the effect of cinnamaldehyde on IGF-I signaling. Treatment with cinnamaldehyde significantly increased the phosphorylation levels of the IGF-I receptor and its downstream signaling molecules such as insulin receptor substrate-1 and Erk1/2 in an IGF-I-independent manner. These results suggested that cinnamon extract is useful in antiaging treatment of skin.
随着年龄的增长，胶原蛋白网络的分解会导致皮肤活动减弱。因此，恢复停滞的胶原蛋白合成有助于保护皮肤真皮组织的内稳态，防止衰老。我们使用人真皮成纤维细胞在各种食物中寻找诱导 I 型胶原蛋白生物合成的物质，发现肉桂提取物能促进胶原蛋白的生物合成。肉桂提取物在没有细胞毒性的情况下，强烈地上调 I 型胶原蛋白的 mRNA 和蛋白表达水平。通过 HPLC 和 NMR 分析，我们确定肉桂醛是促进胶原蛋白表达的主要活性成分。由于胰岛素样生长因子-I（IGF-I）是成纤维细胞中最有效的胶原蛋白生物合成刺激物，我们研究了肉桂醛对 IGF-I 信号的影响。肉桂醛处理以 IGF-I 非依赖性方式显著增加 IGF-I 受体及其下游信号分子如胰岛素受体底物-1 和 Erk1/2 的磷酸化水平。这些结果表明，肉桂提取物在皮肤抗衰老治疗中是有用的。
