Isaac P A, Rosen M
Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff.
Br J Anaesth. 1990 Sep;65(3):319-24. doi: 10.1093/bja/65.3.319.
We have investigated the value of lower oesophageal contractility (LOC) in detecting awareness during anaesthesia in 20 human volunteer patients. LOC was measured either with subjects awake or after induction with propofol, during induction with propofol, and then as consciousness returned. Statistically significant changes were observed in the frequency of spontaneous contractions, peak and mean amplitude of spontaneous and provoked contractions, and the oesophageal contractility index as subjects lost consciousness and also as it was regained. The differences in LOC which occurred when subjects were conscious and unconscious support the view that LOC is related to the depth of anaesthesia, but its unreliability at the interface between consciousness and unconsciousness prevents selective detection of awareness, although the response in the presence of painful stimuli has not been tested.
我们研究了20名志愿者患者在麻醉期间食管下段收缩性（LOC）对于检测术中知晓的价值。分别在受试者清醒时、丙泊酚诱导后、丙泊酚诱导期间以及意识恢复时测量LOC。在受试者失去意识以及意识恢复过程中，观察到自发性收缩频率、自发性和诱发性收缩的峰值及平均幅度，以及食管收缩性指数存在统计学上的显著变化。受试者意识清醒和无意识时LOC的差异支持了LOC与麻醉深度相关的观点，但其在意识与无意识交界状态下的不可靠性妨碍了对术中知晓的选择性检测，尽管尚未测试其在疼痛刺激存在时的反应。
