Thornton C, Konieczko K M, Knight A B, Kaul B, Jones J G, Dore C J, White D C
Clinical Research Centre, Harrow, Middlesex.
Br J Anaesth. 1989 Oct;63(4):411-7. doi: 10.1093/bja/63.4.411.
Six patients were anaesthetized with 70% nitrous oxide in oxygen supplemented by infusion of propofol 40, 80, 120, 160 and 200 micrograms kg-1 min-1 sequentially in successive 10-min periods. Auditory evoked response (AER) and lower oesophageal contractility (LOC) were monitored. The AER findings were consistent with those noted in previous studies of i.v. agents. Early cortical waves showed attenuation of Pa and Nb amplitude (P less than 0.01) and increase in Pa and Nb latency (P less than 0.01; P less than 0.05) with increasing blood concentrations of propofol. Brainstem waves were not affected significantly. LOC, provoked and spontaneous, showed no consistent relationship with blood concentration of propofol. The two variables AER and LOC were not related.
六名患者在补充了氧气的70%氧化亚氮中麻醉，依次在连续的10分钟时间段内输注40、80、120、160和200微克/千克/分钟的丙泊酚。监测听觉诱发电位（AER）和食管下段收缩性（LOC）。AER的结果与先前关于静脉用药的研究结果一致。随着丙泊酚血药浓度的增加，早期皮质波显示Pa和Nb波幅衰减（P<0.01）以及Pa和Nb潜伏期延长（P<0.01；P<0.05）。脑干波未受到显著影响。诱发和自发的LOC与丙泊酚血药浓度未显示出一致的关系。AER和LOC这两个变量不相关。
